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DAK1 dihydroxyacetone kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854932, updated on 17-May-2024

Summary

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Gene symbol
DAK1
Gene description
dihydroxyacetone kinase
Primary source
FungiDB:YML070W
Locus tag
YML070W
See related
SGD:S000004535; AllianceGenome:SGD:S000004535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycerone kinase activity. Involved in cellular response to toxic substance and glycerol to glycerone phosphate metabolic process. Located in cytoplasm. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (133475..135229)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG8 Neighboring gene tRNA-Arg Neighboring gene FACT complex subunit POB3 Neighboring gene RBR-type E3 ubiquitin transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as 'non-fermentable'. Aßkamp MR, et al. Biotechnol Biofuels, 2019. PMID 31695748, Free PMC Article
  2. Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1. Lee H, et al. Biochem Biophys Res Commun, 2009 Nov 6. PMID 19715675
  3. Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenorhabditis elegans. Molin M, et al. Proteomics, 2007 Oct. PMID 17890650
  4. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin M, et al. Mol Microbiol, 2006 May. PMID 16677304
  5. Fragmentation of dihydroxyacetone kinase 1 from Saccharomyces cerevisiae indicates a two-domain structure. Molin M, et al. Proteomics, 2003 May. PMID 12748953

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpx3 interacts with Dak1, alleviates dihydroxyacetone-mediated stress by upregulating Dak activity, and consequently suppresses advanced glycation endproducts formation.
    Title: Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glycerone kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables triokinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol to glycerone phosphate metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dihydroxyacetone kinase
NP_013641.1
  • Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    133475..135229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182429.1 → NP_013641.1  TPA: dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013641.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZA3, P54838
    UniProtKB/TrEMBL
    A0A6L0ZE62, A6ZLZ5, C7GW06, G2WJY5, N1P0U3
    Conserved Domains (1) summary
    TIGR02361
    Location:5 → 581
    dak_ATP; dihydroxyacetone kinase, ATP-dependent
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54838.1

Gene LinkOut

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