CAT2 carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CAT2
Gene description: carnitine O-acetyltransferase CAT2
Primary source: SGD:S000004506
Locus tag: YML042W
See related: AllianceGenome:SGD:S000004506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YCAT
Summary: Enables carnitine O-acetyltransferase activity. Involved in carnitine metabolic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in Alzheimer's disease; congenital myasthenic syndrome 6; and neurodegeneration with brain iron accumulation. Orthologous to several human genes including CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (192788..194800)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that carnitine protects cells from oxidative and organic acid stress, while CAT2 contributes to the response to oxidative stress.
Title: Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine O-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in carnitine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carnitine O-acetyltransferase CAT2

NP_013670.1

EC 2.3.1.7

Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

192788..194800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182400.1 → NP_013670.1 TPA: carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013670.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZD3, P32796

UniProtKB/TrEMBL

A0A8H4BX41, G2WK13, N1P0W9

Conserved Domains (1) summary

pfam00755
Location:74 → 657

Carn_acyltransf; Choline/Carnitine o-acyltransferase