APT1 adenine phosphoribosyltransferase APT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: APT1
Gene description: adenine phosphoribosyltransferase APT1
Primary source: SGD:S000004484
Locus tag: YML022W
See related: AllianceGenome:SGD:S000004484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenine phosphoribosyltransferase activity. Involved in adenine salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
Title: The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
crystals of Apt1 diffracted to 2.40 A resolution and belonged to space group P4(2)2(1)2, with unit-cell parameters a = b = 146.43, c = 93.29 A
Title: Cloning, purification, crystallization and preliminary X-ray diffraction crystallographic study of acyl-protein thioesterase 1 from Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables adenine binding	IBA Inferred from Biological aspect of Ancestor more info
enables adenine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenine phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
involved_in adenine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine salvage	IEA Inferred from Electronic Annotation more info
involved_in adenine salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_013690.1

Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication