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ERG5 C-22 sterol desaturase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855029, updated on 13-Apr-2024

Summary

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Gene symbol
ERG5
Gene description
C-22 sterol desaturase
Primary source
SGD:S000004617
Locus tag
YMR015C
See related
AllianceGenome:SGD:S000004617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CYP61
Summary
Enables C-22 sterol desaturase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to several human genes including CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ERG5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (300869..302485, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Bud22p Neighboring gene Sok2p Neighboring gene Spo20p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses. Liu G, et al. FEMS Yeast Res, 2017 Sep 1. PMID 28910986
  2. Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. Su W, et al. PLoS One, 2015. PMID 26098102, Free PMC Article
  3. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. Kelly SL, et al. J Biol Chem, 1997 Apr 11. PMID 9092539
  4. Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. Skaggs BA, et al. Gene, 1996 Feb 22. PMID 8635732
  5. Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol delta 22-desaturase. Kelly SL, et al. FEBS Lett, 1995 Dec 18. PMID 8543054

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables C-22 sterol desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-22 sterol desaturase
NP_013728.1
  • C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    300869..302485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182511.1 → NP_013728.1  TPA: C-22 sterol desaturase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013728.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZI9, E9P965, P54781
    UniProtKB/TrEMBL
    A0A6A5PQ83, A6ZM77, B3LLR7, B5VPE2, C7GLA4, C8ZEM3, G2WK66, N1NX58
    Conserved Domains (1) summary
    cd11082
    Location:103 → 522
    CYP61_CYP710; C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54781.1

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