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STV1 H(+)-transporting V0 sector ATPase subunit a [ Saccharomyces cerevisiae S288C ]

Gene ID: 855076, updated on 13-Apr-2024

Summary

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Gene symbol
STV1
Gene description
H(+)-transporting V0 sector ATPase subunit a
Primary source
SGD:S000004658
Locus tag
YMR054W
See related
AllianceGenome:SGD:S000004658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol-4-phosphate binding activity. Contributes to proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in Golgi apparatus and late endosome. Part of vacuolar proton-transporting V-type ATPase, V0 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (383303..385975)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Far3p Neighboring gene Stb2p Neighboring gene Bub2p Neighboring gene ADP/ATP carrier protein AAC1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and localization of an essential transmembrane segment of the proton translocation channel of yeast H+-V-ATPase. Duarte AM, et al. Biochim Biophys Acta, 2007 Feb. PMID 16962559
  2. Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p. Finnigan GC, et al. J Biol Chem, 2012 Jun 1. PMID 22496448, Free PMC Article
  3. Dependence of Saccharomyces cerevisiae Golgi functions on V-ATPase activity. Corbacho I, et al. FEMS Yeast Res, 2012 May. PMID 22212511
  4. The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae. Finnigan GC, et al. Mol Biol Cell, 2011 Sep. PMID 21737673, Free PMC Article
  5. Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity. Qi J, et al. J Biol Chem, 2007 Aug 24. PMID 17565997, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STV1 overexpression suppressed the growth defects of both rav1 and rav1vph1, and allowed RAVE-independent assembly of active Stv1p-containing V-ATPases in vacuoles.
    Title: The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast.
  2. This evolutionary intermediate includes an endogenous W(83)KY sorting motif and is sufficient to compete with sorting of the native yeast Stv1p V-ATPase isoform.
    Title: Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar acidification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain IDA
Inferred from Direct Assay
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
H(+)-transporting V0 sector ATPase subunit a
NP_013770.1
  • Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    383303..385975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182552.1 → NP_013770.1  TPA: H(+)-transporting V0 sector ATPase subunit a [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZM9, P37296
    UniProtKB/TrEMBL
    A0A8H4F9F5, A6ZMB4, B3LLU8, C7GL69, G2WKA3, N1NY87
    Conserved Domains (1) summary
    pfam01496
    Location:32 → 885
    V_ATPase_I; V-type ATPase 116kDa subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6O7V_a.1
6O7W_a.1
6O7X_a.1
P37296.2

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