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ARG7 glutamate N-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855084, updated on 13-Apr-2024

Summary

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Gene symbol
ARG7
Gene description
glutamate N-acetyltransferase
Primary source
SGD:S000004666
Locus tag
YMR062C
See related
AllianceGenome:SGD:S000004666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ECM40
Summary
Enables acetyl-CoA:L-glutamate N-acetyltransferase activity. Involved in ornithine biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (395054..396379, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene SAM complex subunit SAM37 Neighboring gene cleavage polyadenylation factor subunit RNA14 Neighboring gene Rim9p Neighboring gene Aep1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization of ornithine acetyltransferase from yeast by counter-diffusion and preliminary X-ray study. Maes D, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Dec 1. PMID 17142921, Free PMC Article
  2. The yeast ARG7 gene product is autoproteolyzed to two subunit peptides, yielding active ornithine acetyltransferase. Abadjieva A, et al. J Biol Chem, 2000 Apr 14. PMID 10753950
  3. Characterization of the Saccharomyces cerevisiae ARG7 gene encoding ornithine acetyltransferase, an enzyme also endowed with acetylglutamate synthase activity. Crabeel M, et al. Eur J Biochem, 1997 Dec 1. PMID 9428669
  4. Purification and characterization of ornithine acetyltransferase from Saccharomyces cerevisiae. Liu Y, et al. Eur J Biochem, 1995 Mar 1. PMID 7705341
  5. The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Pauwels K, et al. Eur J Biochem, 2003 Mar. PMID 12603335

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystals belong to space group P4, with unit-cell parameters a = b = 66.98, c = 427.09 A, and a data set was collected to 2.76 A.
    Title: Crystallization of ornithine acetyltransferase from yeast by counter-diffusion and preliminary X-ray study.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyl-CoA:L-glutamate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA:L-glutamate N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA:L-glutamate N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methione N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ornithine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ornithine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate N-acetyltransferase
NP_013778.1
  • Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    395054..396379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182560.1 → NP_013778.1  TPA: glutamate N-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013778.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZMC1, B3LLV5, B5VPI9, C7GL62, C8ZER4, D6VZN6, Q04682, Q04728, Q09168
    UniProtKB/TrEMBL
    A0A6A5PPK7, G2WKB0, N1NYP4
    Conserved Domains (1) summary
    TIGR00120
    Location:22 → 441
    ArgJ; glutamate N-acetyltransferase/amino-acid acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04728.1

Gene LinkOut

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