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FOL3 dihydrofolate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855140, updated on 11-Apr-2024

Summary

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Gene symbol
FOL3
Gene description
dihydrofolate synthase
Primary source
SGD:S000004719
Locus tag
YMR113W
See related
AllianceGenome:SGD:S000004719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydrofolate synthase activity. Involved in folic acid-containing compound biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (494999..496282)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Euc1p Neighboring gene Med11p Neighboring gene putative peptide hydrolase Neighboring gene Mgr3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of the Pneumocystis carinii dihydrofolate synthase gene and functional complementation in Saccharomyces cerevisiae. Hauser PM, et al. FEMS Microbiol Lett, 2006 Mar. PMID 16499613
  2. Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. Bayly AM, et al. FEMS Microbiol Lett, 2001 Nov 13. PMID 11731153
  3. Nutritional control of epigenetic processes in yeast and human cells. Sadhu MJ, et al. Genetics, 2013 Nov. PMID 23979574, Free PMC Article
  4. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Salcedo E, et al. Mol Biochem Parasitol, 2001 Feb. PMID 11223131
  5. Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. Cherest H, et al. J Biol Chem, 2000 May 12. PMID 10799479

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acid-amino acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrofolate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrofolate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrofolate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tetrahydrofolylpolyglutamate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tetrahydrofolylpolyglutamate synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dihydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in folic acid-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dihydrofolate synthase
NP_013831.1
  • Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    494999..496282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182613.1 → NP_013831.1  TPA: dihydrofolate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013831.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT6, Q12676
    UniProtKB/TrEMBL
    A0A8H4F824, A6ZMH0, B3LM04, C7GW96, C8ZEW6, G2WKG3, N1NXC5
    Conserved Domains (1) summary
    COG0285
    Location:3 → 427
    FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12676.1

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