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GAD1 glutamate decarboxylase GAD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855291, updated on 17-May-2024

Summary

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Gene symbol
GAD1
Gene description
glutamate decarboxylase GAD1
Primary source
FungiDB:YMR250W
Locus tag
YMR250W
See related
SGD:S000004862; AllianceGenome:SGD:S000004862; VEuPathDB:YMR250W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutamate decarboxylase activity. Involved in cellular response to oxidative stress and glutamate catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GAD1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (770801..772558)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase Neighboring gene Hor7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. Kamei Y, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21371425
  2. GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production. Cao J, et al. Yeast, 2013 Apr. PMID 23447388
  3. New insights into {gamma}-aminobutyric acid catabolism: Evidence for {gamma}-hydroxybutyric acid and polyhydroxybutyrate synthesis in Saccharomyces cerevisiae. Bach B, et al. Appl Environ Microbiol, 2009 Jul. PMID 19411412, Free PMC Article
  4. Alanine Represses γ-Aminobutyric Acid Utilization and Induces Alanine Transaminase Required for Mitochondrial Function in Saccharomyces cerevisiae. Márquez D, et al. Front Microbiol, 2021. PMID 34421848, Free PMC Article
  5. Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. Coleman ST, et al. J Biol Chem, 2001 Jan 5. PMID 11031268

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
    Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
  2. UGA1 and GAD1 were identified as aging genes.
    Title: GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutamate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamate decarboxylase GAD1
NP_013976.1
  • Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    770801..772558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182756.1 → NP_013976.1  TPA: glutamate decarboxylase GAD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W076, Q04792
    UniProtKB/TrEMBL
    A6ZMW5, B3LMD8, B5VQ18, C7GRA2, C8ZFB5, D0VFN3, G2WKV8
    Conserved Domains (1) summary
    TIGR01788
    Location:41 → 522
    Glu-decarb-GAD; glutamate decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04792.1

Gene LinkOut

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