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URA10 orotate phosphoribosyltransferase URA10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855313, updated on 17-May-2024

Summary

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Gene symbol
URA10
Gene description
orotate phosphoribosyltransferase URA10
Primary source
FungiDB:YMR271C
Locus tag
YMR271C
See related
SGD:S000004884; AllianceGenome:SGD:S000004884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables orotate phosphoribosyltransferase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleoside biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (806865..807548, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Tma23p Neighboring gene Rrn9p Neighboring gene tRNA-Gln Neighboring gene fatty acid alpha-hydroxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. QM/MM reveals the sequence of substrate binding during OPRT action. Subrahmanyeswara Rao NN, et al. Comput Biol Chem, 2018 Jun. PMID 29533816
  2. Cloning and sequencing of URA10, a second gene encoding orotate phosphoribosyl transferase in Saccharomyces cerevisiae. de Montigny J, et al. Curr Genet, 1990 Feb. PMID 2182197
  3. Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast. Victor J, et al. J Biol Chem, 1979 Apr 25. PMID 218950
  4. The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation. Hohmann S, et al. Curr Genet, 1994 Oct. PMID 7882422
  5. Purification and properties of orotidine-5'-phosphate pyrophosphorylase and orotidine-5'-phosphate decarboxylase from baker's yeast. Umezu K, et al. J Biochem, 1971 Aug. PMID 5094209

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables orotate phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables orotate phosphoribosyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleobase-containing small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine ribonucleoside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine ribonucleoside biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pyrimidine ribonucleoside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
orotate phosphoribosyltransferase URA10
NP_013998.1
  • Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    806865..807548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182778.1 → NP_013998.1  TPA: orotate phosphoribosyltransferase URA10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W097, P30402
    UniProtKB/TrEMBL
    A0A6L1A8K7, A6ZMY6, B3LMF8, B5VQ35, C7GR83, C8ZFD6, N1NYS2
    Conserved Domains (1) summary
    TIGR00336
    Location:17 → 202
    pyrE; orotate phosphoribosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30402.3

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