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HER2 glutamyl-tRNA(Gln) amidotransferase subunit HER2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855338, updated on 13-Apr-2024

Summary

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Gene symbol
HER2
Gene description
glutamyl-tRNA(Gln) amidotransferase subunit HER2
Primary source
SGD:S000004907
Locus tag
YMR293C
See related
AllianceGenome:SGD:S000004907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GEP6; QRS1; RRG6
Summary
Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in endoplasmic reticulum organization and glutaminyl-tRNAGln biosynthesis via transamidation. Located in mitochondrion. Is extrinsic component of mitochondrial inner membrane. Part of glutamyl-tRNA(Gln) amidotransferase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (855399..856793, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene protein kinase TDA1 Neighboring gene Got1p Neighboring gene Jnm1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pathogenic variants in glutamyl-tRNA(Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Friederich MW, et al. Nat Commun, 2018 Oct 3. PMID 30283131, Free PMC Article
  2. Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p. Moda BS, et al. Curr Genet, 2016 Aug. PMID 26780366
  3. Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases. Araiso Y, et al. Nucleic Acids Res, 2014 May. PMID 24692665, Free PMC Article
  4. Her2p molecular modeling, mutant analysis and intramitochondrial localization. Ferreira-Júnior JR, et al. Fungal Genet Biol, 2013 Nov. PMID 23850602
  5. Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase. Barros MH, et al. J Biol Chem, 2011 Sep 23. PMID 21799017, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of yeast mitochondrial GatFAB complex.
    Title: Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit HER2
NP_014021.1
  • Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    855399..856793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182801.1 → NP_014021.1  TPA: glutamyl-tRNA(Gln) amidotransferase subunit HER2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014021.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0C0, Q03557
    UniProtKB/TrEMBL
    A0A8H4BWT5, B3LMI1, B5VQ60
    Conserved Domains (1) summary
    TIGR00132
    Location:1 → 464
    gatA; aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4N0H_A.1
4N0I_A.1
Q03557.1

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