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MET2 homoserine O-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855444, updated on 11-Apr-2024

Summary

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Gene symbol
MET2
Gene description
homoserine O-acetyltransferase
Primary source
SGD:S000005221
Locus tag
YNL277W
See related
AllianceGenome:SGD:S000005221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables homoserine O-acetyltransferase activity. Involved in homoserine metabolic process and methionine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (117349..118809)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Caf120p Neighboring gene uncharacterized protein Neighboring gene Bor1p Neighboring gene glyoxylate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae. Pohl TJ, et al. PLoS Genet, 2012. PMID 22589733, Free PMC Article
  2. Cloning and characterization of the Pichia pastoris MET2 gene as a selectable marker. Thor D, et al. FEMS Yeast Res, 2005 Jul. PMID 15996626
  3. Association of Saccharomyces bayanus var. uvarum with some French wines: genetic analysis of yeast populations. Naumov GI, et al. Res Microbiol, 2000 Oct. PMID 11081582
  4. Inactivation of MET2 in brewer's yeast increases the level of sulfite in beer. Hansen J, et al. J Biotechnol, 1996 Sep 13. PMID 8987848
  5. Regulation of homoserine O-transacetylase, first step in methionine biosyntheis in Saccharomyces cerevisiae. Robichon-Szulmajster H, et al. Biochem Biophys Res Commun, 1967 Jul 21. PMID 6035500

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables homoserine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables homoserine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables homoserine O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables homoserine O-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homoserine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homoserine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homoserine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homoserine O-acetyltransferase
NP_014122.1
  • L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    117349..118809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183115.1 → NP_014122.1  TPA: homoserine O-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014122.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R8, P08465
    UniProtKB/TrEMBL
    A0A023VTP3, C8ZGP5, N1NZW3
    Conserved Domains (1) summary
    TIGR01392
    Location:35 → 449
    homoserO_Ac_trn; homoserine O-acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08465.2

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