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CRS1 cysteine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855474, updated on 5-May-2024

Summary

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Gene symbol
CRS1
Gene description
cysteine--tRNA ligase
Primary source
SGD:S000005191
Locus tag
YNL247W
See related
AllianceGenome:SGD:S000005191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cysteine-tRNA ligase activity. Involved in cysteinyl-tRNA aminoacylation. Located in cytosol and mitochondrion. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (182875..185178)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mpa43p Neighboring gene DNA-directed RNA polymerase I subunit RPA49 Neighboring gene Vps75p Neighboring gene U2-type spliceosomal complex subunit CWC25 Neighboring gene translation initiation factor eIF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation. Hoffman KS, et al. J Biol Chem, 2019 Aug 23. PMID 31296657, Free PMC Article
  2. Cysteinyl-tRNA synthetase from Saccharomyces cerevisiae. Purification, characterization and assignment to the genomic sequence YNL247w. Motorin Y, et al. Biochimie, 1997 Dec. PMID 9523015
  3. Purification and properties of the L-cysteinyl ribonucleic acid synthetase of bakers' yeast. James HL, et al. J Biol Chem, 1969 Jun 25. PMID 4307312
  4. Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase. Lipman RS, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811828, Free PMC Article
  5. Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells. Nishimura A, et al. J Biol Chem, 2019 Sep 13. PMID 31350340, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteinyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteinyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine--tRNA ligase
NP_014152.1
  • Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    182875..185178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183085.1 → NP_014152.1  TPA: cysteine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0U6, P53852
    UniProtKB/TrEMBL
    A0A8H4BWG0, G2WLL9
    Conserved Domains (1) summary
    PTZ00399
    Location:2 → 762
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53852.1

Gene LinkOut

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