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SPS19 2,4-dienoyl-CoA reductase (NADPH) [ Saccharomyces cerevisiae S288C ]

Gene ID: 855518, updated on 17-May-2024

Summary

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Gene symbol
SPS19
Gene description
2,4-dienoyl-CoA reductase (NADPH)
Primary source
FungiDB:YNL202W
Locus tag
YNL202W
See related
SGD:S000005146; AllianceGenome:SGD:S000005146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPX19
Summary
Enables 2,4-dienoyl-CoA reductase (NADPH) activity. Involved in ascospore formation and fatty acid catabolic process. Located in peroxisomal matrix. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPS19 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (259578..260456)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rtt106p Neighboring gene Sps18p Neighboring gene Psy2p Neighboring gene NADHX epimerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the beta-oxidation of trans-unsaturated fatty acid in recombinant Saccharomyces cerevisiae expressing a peroxisomal PHA synthase reveals the involvement of a reductase-dependent pathway. Robert J, et al. Biochim Biophys Acta, 2005 May 15. PMID 15904873
  2. Adr1p-dependent regulation of the oleic acid-inducible yeast gene SPS19 encoding the peroxisomal beta-oxidation auxiliary enzyme 2,4-dienoyl-CoA reductase. Gurvitz A, et al. Mol Cell Biol Res Commun, 2000 Aug. PMID 11170837
  3. A novel element in the promoter of the Saccharomyces cerevisiae gene SPS19 enhances ORE-dependent up-regulation in oleic acid and is essential for de-repression. Gurvitz A, et al. Mol Gen Genet, 1999 Oct. PMID 10589836
  4. Function of human mitochondrial 2,4-dienoyl-CoA reductase and rat monofunctional Delta3-Delta2-enoyl-CoA isomerase in beta-oxidation of unsaturated fatty acids. Gurvitz A, et al. Biochem J, 1999 Dec 15. PMID 10585880, Free PMC Article
  5. Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. Gurvitz A, et al. Biochim Biophys Acta, 2001 Sep 28. PMID 11566445

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2,4-dienoyl-CoA reductase (NADPH)
NP_014197.2
  • Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    259578..260456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183040.1 → NP_014197.2  TPA: 2,4-dienoyl-CoA reductase (NADPH) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014197.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Y6, P32573
    UniProtKB/TrEMBL
    A0A8H4BWY4, A6ZRN6, B3LP48, B5VQK7, C7GTH2, C8ZG29, G2WLQ9, N1NX96
    Conserved Domains (1) summary
    cd05369
    Location:22 → 270
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32573.4

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