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CPT1 diacylglycerol cholinephosphotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855593, updated on 13-Apr-2024

Summary

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Gene symbol
CPT1
Gene description
diacylglycerol cholinephosphotransferase
Primary source
SGD:S000005074
Locus tag
YNL130C
See related
AllianceGenome:SGD:S000005074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables diacylglycerol cholinephosphotransferase activity. Involved in CDP-choline pathway. Located in Golgi apparatus and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to several human genes including SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (379558..380831, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein KRE33 Neighboring gene Tom22p Neighboring gene Dgr1p Neighboring gene ribosylnicotinamide kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast. Griac P, et al. J Biol Chem, 1996 Oct 11. PMID 8810347
  2. Phosphatidylcholine biosynthesis via the CDP-choline pathway in Saccharomyces cerevisiae. Multiple mechanisms of regulation. McMaster CR, et al. J Biol Chem, 1994 May 20. PMID 8182083
  3. Phosphatidylcholine biosynthesis in Saccharomyces cerevisiae. Regulatory insights from studies employing null and chimeric sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases. McMaster CR, et al. J Biol Chem, 1994 Nov 11. PMID 7961735
  4. Mutants of Saccharomyces cerevisiae defective in sn-1,2-diacylglycerol cholinephosphotransferase. Isolation, characterization, and cloning of the CPT1 gene. Hjelmstad RH, et al. J Biol Chem, 1987 Mar 15. PMID 3029130
  5. The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene. Hjelmstad RH, et al. J Biol Chem, 1990 Jan 25. PMID 2153142

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables diacylglycerol cholinephosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol cholinephosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol cholinephosphotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CDP-choline pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diacylglycerol cholinephosphotransferase
NP_014269.4
  • Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    379558..380831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182968.3 → NP_014269.4  TPA: diacylglycerol cholinephosphotransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014269.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W152, P17898
    UniProtKB/TrEMBL
    A6ZRV3, B3LNY7, C8ZGA0
    Conserved Domains (1) summary
    COG5050
    Location:2 → 393
    EPT1; sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17898.3

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