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COX5A cytochrome c oxidase subunit Va [ Saccharomyces cerevisiae S288C ]

Gene ID: 855675, updated on 13-Apr-2024

Summary

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Gene symbol
COX5A
Gene description
cytochrome c oxidase subunit Va
Primary source
SGD:S000004997
Locus tag
YNL052W
See related
AllianceGenome:SGD:S000004997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (531725..532186)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Vac7p Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene Golgi transport complex subunit COG5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial membrane biogenesis: characterization and use of pet mutants to clone the nuclear gene coding for subunit V of yeast cytochrome c oxidase. McEwen JE, et al. J Cell Biochem, 1984. PMID 6330135
  2. Cloning and characterization of the yeast nuclear gene for subunit 5 of cytochrome oxidase. Koerner TJ, et al. J Biol Chem, 1985 Aug 15. PMID 2991248
  3. Primary structure of a gene for subunit V of the cytochrome c oxidase from Saccharomyces cerevisiae. Séraphin B, et al. Curr Genet, 1985. PMID 2836092
  4. A yeast mitochondrial leader peptide functions in vivo as a dual targeting signal for both chloroplasts and mitochondria. Huang J, et al. Plant Cell, 1990 Dec. PMID 1967076, Free PMC Article
  5. An unusual mitochondrial import pathway for the precursor to yeast cytochrome c oxidase subunit Va. Miller BR, et al. J Cell Biol, 1991 Mar. PMID 1847927, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of isoenzymes cox5a and cox5b indicate that the elevated activity of cox5b in the rox1 mutant is not caused by exchange of isoforms.
    Title: Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.
  2. COX5a is switched off and COX5b is switched on when the O2 concentration drops below a threshold of 0.5 microM O2.
    Title: Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit Va
NP_014346.1
  • Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    531725..532186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182891.1 → NP_014346.1  TPA: cytochrome c oxidase subunit Va [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1C7, P00424
    UniProtKB/TrEMBL
    A0A6A5Q8F6, A6ZS26, B3LNR3, C7GLU9, C8ZGH6, G2WM51, N1P4I7
    Conserved Domains (1) summary
    pfam02936
    Location:34 → 152
    COX4; Cytochrome c oxidase subunit IV
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00424.1

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