IDP3 isocitrate dehydrogenase (NADP(+)) IDP3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: IDP3
Gene description: isocitrate dehydrogenase (NADP(+)) IDP3
Primary source: FungiDB:YNL009W
Locus tag: YNL009W
See related: SGD:S000004954; AllianceGenome:SGD:S000004954
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IDP3 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (614821..616083)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S. cerevisiae (Sc) Idp1, Idp2, and Idp3 are highly similar to Homo sapiens (Hs) Idh1 and Idh2 (67, 60 and 59% amino acid identity between Sc Idp1, Idp2, and Idp3, and Hs Idh1, respectively), and the arginine residues corresponding to R100 and R132 in Hs Idh1 (Hs Idh2 R140 and R172) are conserved in the corresponding yeast orthologs
Title: Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast.
Title: Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isocitrate dehydrogenase (NADP(+)) IDP3

NP_014389.3

EC 1.1.1.42

Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

614821..616083

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182848.3 → NP_014389.3 TPA: isocitrate dehydrogenase (NADP(+)) IDP3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014389.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1G8, P53982

UniProtKB/TrEMBL

A0A8H4BY63, A6ZS67, N1NWR1

Conserved Domains (1) summary

PRK08299
Location:1 → 407

PRK08299; NADP-dependent isocitrate dehydrogenase