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LRO1 phospholipid:diacylglycerol acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855742, updated on 13-Apr-2024

Summary

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Gene symbol
LRO1
Gene description
phospholipid:diacylglycerol acyltransferase
Primary source
SGD:S000005291
Locus tag
YNR008W
See related
AllianceGenome:SGD:S000005291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid:diacylglycerol acyltransferase activity. Involved in several processes, including lipid storage; phospholipid homeostasis; and triglyceride biosynthetic process. Located in lipid droplet; nuclear inner membrane; and perinuclear endoplasmic reticulum. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase) and PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (640396..642381)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ESCRT-0 subunit protein VPS27 Neighboring gene Atg3p Neighboring gene Nrm1p Neighboring gene Cse2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expanding of Phospholipid:Diacylglycerol AcylTransferase (PDAT) from Saccharomyces cerevisiae as Multifunctional Biocatalyst with Broad Acyl Donor/Acceptor Selectivity. Feng Y, et al. Appl Biochem Biotechnol, 2019 Jul. PMID 30706417
  2. Saccharomyces cerevisiae phospholipid:diacylglycerol acyl transferase (PDAT) devoid of its membrane anchor region is a soluble and active enzyme retaining its substrate specificities. Ghosal A, et al. Biochim Biophys Acta, 2007 Dec. PMID 18037386
  3. YALI0E32769g (DGA1) and YALI0E16797g (LRO1) encode major triacylglycerol synthases of the oleaginous yeast Yarrowia lipolytica. Athenstaedt K. Biochim Biophys Acta, 2011 Oct. PMID 21782973, Free PMC Article
  4. Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae. Sorger D, et al. J Bacteriol, 2002 Jan. PMID 11751830, Free PMC Article
  5. Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization. Barbosa AD, et al. Dev Cell, 2019 Sep 23. PMID 31422915, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid:diacylglycerol acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid:diacylglycerol acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid:diacylglycerol acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phospholipid:diacylglycerol acyltransferase
NP_014405.1
  • Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    640396..642381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183185.1 → NP_014405.1  TPA: phospholipid:diacylglycerol acyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014405.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1I3, P40345
    UniProtKB/TrEMBL
    A0A8H4BWW1, A6ZS82, B3LPN2, C7GLP7, C8ZFN5, G2WL65, N1NZN8
    Conserved Domains (1) summary
    pfam02450
    Location:206 → 625
    LCAT; Lecithin:cholesterol acyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40345.1

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