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URK1 uridine kinase URK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855746, updated on 11-Apr-2024

Summary

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Gene symbol
URK1
Gene description
uridine kinase URK1
Primary source
SGD:S000005295
Locus tag
YNR012W
See related
AllianceGenome:SGD:S000005295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables uridine kinase activity. Involved in pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See URK1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (647432..648937)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cse2p Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene Pho91p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase. Kern L. Nucleic Acids Res, 1990 Sep 11. PMID 2169608, Free PMC Article
  2. The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Kurtz JE, et al. Curr Genet, 2002 Jun. PMID 12111094
  3. Enhancement of cloned gene product synthesis via autoselection in recombinant Saccharomyces cerevisiae. Napp SJ, et al. Biotechnol Bioeng, 1993 Apr 5. PMID 18609624
  4. Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Mitterbauer R, et al. Appl Environ Microbiol, 2002 Mar. PMID 11872485, Free PMC Article
  5. Improved protein synthesis and secretion through medium enrichment in a stable recombinant yeast strain. Wang Z, et al. Biotechnol Bioeng, 1993 Jun 5. PMID 18609652

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in CMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine-containing compound salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine-containing compound salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uridine kinase URK1
NP_014409.1
  • Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    647432..648937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183189.1 → NP_014409.1  TPA: uridine kinase URK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1I7, P27515
    UniProtKB/TrEMBL
    A0A8H4BVW2, B5VR43, C7GLP3, N1NY55
    Conserved Domains (2) summary
    COG0035
    Location:280 → 501
    Upp; Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]
    TIGR00235
    Location:69 → 260
    udk; uridine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27515.1

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