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BIO3 adenosylmethionine-8-amino-7-oxononanoate transaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855795, updated on 13-Apr-2024

Summary

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Gene symbol
BIO3
Gene description
adenosylmethionine-8-amino-7-oxononanoate transaminase
Primary source
SGD:S000005341
Locus tag
YNR058W
See related
AllianceGenome:SGD:S000005341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity. Involved in biotin biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (734291..735733)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Bio5p Neighboring gene dethiobiotin synthase Neighboring gene putative alpha-1,3-mannosyltransferase Neighboring gene ferric-chelate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. Hall C, et al. Genetics, 2007 Dec. PMID 18073433, Free PMC Article
  2. Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Phalip V, et al. Gene, 1999 May 17. PMID 10333520
  3. A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling. Brice C, et al. BMC Genomics, 2014 Jun 19. PMID 24947828, Free PMC Article
  4. Identification by comparative transcriptomics of core regulatory genes for higher alcohol production in a top-fermenting yeast at different temperatures in beer fermentation. Sun ZG, et al. Appl Microbiol Biotechnol, 2019 Jun. PMID 31073877
  5. Yeast genes involved in sulfur and nitrogen metabolism affect the production of volatile thiols from Sauvignon Blanc musts. Harsch MJ, et al. Appl Microbiol Biotechnol, 2013 Jan. PMID 22684328

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quantitative trait loci analysis suggest that polymorphism in the coding region of GCN1, MDS3, ARG81 and BIO3 could account for differences in nitrogen requirement.
    Title: A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables dethiobiotin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosylmethionine-8-amino-7-oxononanoate transaminase
NP_014456.1
  • 7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    734291..735733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183235.1 → NP_014456.1  TPA: adenosylmethionine-8-amino-7-oxononanoate transaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014456.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1N3, E9P967, P50277, Q4R1J0
    UniProtKB/TrEMBL
    A0A8H4BVY9, A6ZSD2, B3LPI5, C7GIY7, C8ZFT7
    Conserved Domains (1) summary
    cl18945
    Location:15 → 472
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50277.1

Gene LinkOut

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