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HXT17 hexose transporter HXT17 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855809, updated on 13-Apr-2024

Summary

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Gene symbol
HXT17
Gene description
hexose transporter HXT17
Primary source
SGD:S000005355
Locus tag
YNR072W
See related
AllianceGenome:SGD:S000005355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HLT4
Summary
Enables fructose transmembrane transporter activity; glucose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport; mannitol transport; and sorbitol transport. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (772657..774351)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette multidrug transporter PDR18 Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene putative mannitol dehydrogenase Neighboring gene Aif1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress. Greatrix BW, et al. Curr Genet, 2006 Apr. PMID 16397765
  2. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article
  3. Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. Liu Z, et al. J Biol Chem, 2004 Apr 23. PMID 14966117
  4. Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. Scarcelli JJ, et al. FEMS Yeast Res, 2012 May. PMID 22151002, Free PMC Article
  5. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sorbitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hexose transporter HXT17
NP_014470.1
  • Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    772657..774351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183249.1 → NP_014470.1  TPA: hexose transporter HXT17 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014470.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1P7, P53631
    UniProtKB/TrEMBL
    A0A8H4BWX9, A6ZSE6, C8ZFU9
    Conserved Domains (1) summary
    pfam00083
    Location:60 → 521
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53631.1

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