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CDC60 leucine--tRNA ligase CDC60 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855943, updated on 17-May-2024

Summary

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Gene symbol
CDC60
Gene description
leucine--tRNA ligase CDC60
Primary source
FungiDB:YPL160W
Locus tag
YPL160W
See related
SGD:S000006081; AllianceGenome:SGD:S000006081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation and regulation of TORC1 signaling. Located in cytoplasm. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC60 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (246990..250262)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bem4p Neighboring gene Pet20p Neighboring gene Aim44p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino-acid-dependent shift in tRNA synthetase editing mechanisms. Sarkar J, et al. J Am Chem Soc, 2011 Nov 23. PMID 22017352, Free PMC Article
  2. Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap. Sarkar J, et al. FEBS Lett, 2011 Oct 3. PMID 21856301, Free PMC Article
  3. Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain. Yao P, et al. J Biol Chem, 2008 Aug 15. PMID 18550527
  4. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Rock FL, et al. Science, 2007 Jun 22. PMID 17588934
  5. Crystallization of tRNA Leu -synthetase from baker's yeast. Chirikjian JG, et al. Proc Natl Acad Sci U S A, 1972 Jun. PMID 4504381, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leucine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables leucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leucyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of TORC1 signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine--tRNA ligase CDC60
NP_015165.1
  • Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    246990..250262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183974.1 → NP_015165.1  TPA: leucine--tRNA ligase CDC60 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3K8, P26637
    UniProtKB/TrEMBL
    A0A8H4BTR9, A6ZW93, B3LKR7, C7GJB2, N1NW09
    Conserved Domains (1) summary
    TIGR00395
    Location:17 → 1088
    leuS_arch; leucyl-tRNA synthetase, archaeal and cytosolic family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26637.1

Gene LinkOut

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