PXA1 ATP-binding cassette long-chain fatty acid transporter PXA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PXA1
Gene description: ATP-binding cassette long-chain fatty acid transporter PXA1
Primary source: SGD:S000006068
Locus tag: YPL147W
See related: AllianceGenome:SGD:S000006068
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPI1; PAL1; PAT2; SSH2
Summary: Enables ATPase-coupled transmembrane transporter activity. Involved in fatty acid transport. Is integral component of peroxisomal membrane. Colocalizes with peroxisome. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in Zellweger syndrome; adrenoleukodystrophy; and congenital bile acid synthesis defect 5. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1) and ABCD2 (ATP binding cassette subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PXA1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (273255..275867)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome.
Title: The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome.
Proteasome-dependent protein quality control of the peroxisomal membrane protein Pxa1p.
Title: Proteasome-dependent protein quality control of the peroxisomal membrane protein Pxa1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into peroxisome	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette long-chain fatty acid transporter PXA1

NP_015178.1

Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

273255..275867

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183961.1 → NP_015178.1 TPA: ATP-binding cassette long-chain fatty acid transporter PXA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015178.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3M2, P41909

UniProtKB/TrEMBL

A0A8H4BVU8, G2WP36, N1P1G2

Conserved Domains (1) summary

TIGR00954
Location:113 → 827

3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein