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CAR1 arginase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855993, updated on 11-Apr-2024

Summary

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Gene symbol
CAR1
Gene description
arginase
Primary source
SGD:S000006032
Locus tag
YPL111W
See related
AllianceGenome:SGD:S000006032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPH15
Summary
Enables arginase activity; ornithine carbamoyltransferase inhibitor activity; and transition metal ion binding activity. Involved in arginine catabolic process to ornithine and regulation of ornithine metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (339944..340945)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pex25p Neighboring gene tRNA-Met Neighboring gene glycerophosphocholine phosphodiesterase Neighboring gene Cqd1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CAR1 deletion by CRISPR/Cas9 reduces formation of ethyl carbamate from ethanol fermentation by Saccharomyces cerevisiae. Chin YW, et al. J Ind Microbiol Biotechnol, 2016 Nov. PMID 27573438
  2. Reduced production of ethyl carbamate for wine fermentation by deleting CAR1 in Saccharomyces cerevisiae. Guo XW, et al. J Ind Microbiol Biotechnol, 2016 May. PMID 26831650
  3. Decreased ethyl carbamate generation during Chinese rice wine fermentation by disruption of CAR1 in an industrial yeast strain. Wu D, et al. Int J Food Microbiol, 2014 Jun 16. PMID 24769164
  4. Contribution of the fermenting yeast strain to ethyl carbamate generation in stone fruit spirits. Schehl B, et al. Appl Microbiol Biotechnol, 2007 Mar. PMID 17216464
  5. Antisense-mediated inhibition of arginase (CAR1) gene expression in Saccharomyces cerevisiae. Park H, et al. J Biosci Bioeng, 2001. PMID 16233134

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ornithine carbamoyltransferase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ornithine carbamoyltransferase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine catabolic process to ornithine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginine catabolic process to ornithine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ornithine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ornithine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of primary metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in urea cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
arginase
NP_015214.1
  • Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    339944..340945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183925.1 → NP_015214.1  TPA: arginase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015214.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Q6, P00812
    UniProtKB/TrEMBL
    A0A6L1C3U4, A6ZWE0, B3LKW2, B5VT53, C7GJ65, G2WP70, N1NW27
    Conserved Domains (1) summary
    TIGR01229
    Location:16 → 333
    rocF_arginase; arginase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00812.1

Gene LinkOut

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