U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ISM1 isoleucine--tRNA ligase ISM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856067, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
ISM1
Gene description
isoleucine--tRNA ligase ISM1
Primary source
FungiDB:YPL040C
Locus tag
YPL040C
See related
SGD:S000005961; AllianceGenome:SGD:S000005961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable isoleucine-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Used to study mitochondrial metabolism disease. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (475993..479001, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene cyclin-dependent serine/threonine protein kinase SSN3 Neighboring gene Mrx11p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron. Boniecki MT, et al. J Biol Chem, 2009 Sep 25. PMID 19622748, Free PMC Article
  2. The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7). Charizanis C, et al. Mol Gen Genet, 1999 Oct. PMID 10589830
  3. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
  4. Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle. Montanari A, et al. RNA, 2011 Nov. PMID 21914842, Free PMC Article
  5. A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria. Karkhanis VA, et al. J Biol Chem, 2006 Nov 3. PMID 16956879

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
isoleucine--tRNA ligase ISM1
NP_015285.1
  • Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    475993..479001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183854.1 → NP_015285.1  TPA: isoleucine--tRNA ligase ISM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015285.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3X3, P48526
    UniProtKB/TrEMBL
    A0A8H4F6T9, A6ZWK7, N1NVI2
    Conserved Domains (1) summary
    TIGR00392
    Location:35 → 920
    ileS; isoleucyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48526.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous