U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ERG10 acetyl-CoA C-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856079, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
ERG10
Gene description
acetyl-CoA C-acetyltransferase
Primary source
SGD:S000005949
Locus tag
YPL028W
See related
AllianceGenome:SGD:S000005949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPB3; TSM0115
Summary
Enables acetyl-CoA C-acetyltransferase activity. Involved in ergosterol biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (498096..499292)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA (uracil) methyltransferase Neighboring gene ATP-dependent RNA helicase SUV3 Neighboring gene Sma1p Neighboring gene putative serine/threonine protein kinase SKS1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae. Zhou P, et al. Acta Crystallogr F Struct Biol Commun, 2018 Jan 1. PMID 29372902, Free PMC Article
  2. Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols. Torres-Salas P, et al. Biochemistry, 2018 Feb 27. PMID 29360348
  3. Production of (S)-3-hydroxybutyrate by metabolically engineered Saccharomyces cerevisiae. Yun EJ, et al. J Biotechnol, 2015 Sep 10. PMID 26026703
  4. Pyridines and pyrimidines mediating activity against an efflux-negative strain of Candida albicans through putative inhibition of lanosterol demethylase. Buurman ET, et al. Antimicrob Agents Chemother, 2004 Jan. PMID 14693556, Free PMC Article
  5. Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae. Dimster-Denk D, et al. Mol Cell Biol, 1996 Aug. PMID 8754796, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of apo ERG10 and its Cys91Ala variant were solved at resolutions of 2.2 and 1.95 A, respectively. ERG10 shares the characteristic thiolase superfamily fold, with a similar active-site architecture to those of type II thiolases and a similar binding pocket, apart from Ala159 at the entrance to the pantetheine-binding cavity, which appears to be a determinant of the poor binding ability of the substrate.
    Title: Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae.
  2. Erg10 thiolase from Saccharomyces cerevisiae showed no acetyl-CoA/butyryl-CoA branched condensation activity, but variants at position F293 resulted the most active and selective biocatalysts for this reaction.
    Title: Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl-CoA C-acetyltransferase
NP_015297.1
  • Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    498096..499292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183842.1 → NP_015297.1  TPA: acetyl-CoA C-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y5, P41338
    UniProtKB/TrEMBL
    A0A6A5Q2W3, A6ZWL9, B3LL36, B5VTD5, C7GU24, C8ZJ01, G2WPF1, N1NW56
    Conserved Domains (1) summary
    PLN02644
    Location:4 → 396
    PLN02644; acetyl-CoA C-acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41338.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous