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ICL2 methylisocitrate lyase ICL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856114, updated on 11-Apr-2024

Summary

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Gene symbol
ICL2
Gene description
methylisocitrate lyase ICL2
Primary source
SGD:S000006210
Locus tag
YPR006C
See related
AllianceGenome:SGD:S000006210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables methylisocitrate lyase activity. Involved in propionate catabolic process, 2-methylcitrate cycle. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (567269..568996, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aim45p Neighboring gene Hal1p Neighboring gene Rec8p Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae. Heinisch JJ, et al. Yeast, 1996 Oct. PMID 8923733
  2. Metabolic adaptation via regulated enzyme degradation in the pathogenic yeast Candida albicans. Ting SY, et al. J Mycol Med, 2017 Mar. PMID 28041812
  3. The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. Luttik MA, et al. J Bacteriol, 2000 Dec. PMID 11092862, Free PMC Article
  4. Metabolic diversification of cells during the development of yeast colonies. Váchová L, et al. Environ Microbiol, 2009 Feb. PMID 19196279
  5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylisocitrate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylisocitrate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylisocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in propionate catabolic process, 2-methylcitrate cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in propionate catabolic process, 2-methylcitrate cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methylisocitrate lyase ICL2
NP_015331.1
  • 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    567269..568996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184103.1 → NP_015331.1  TPA: methylisocitrate lyase ICL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015331.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W417, Q12031
    UniProtKB/TrEMBL
    A0A8H4BV79, B3LL67, N1P1Y9
    Conserved Domains (1) summary
    COG2224
    Location:39 → 575
    AceA; Isocitrate lyase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12031.1

Gene LinkOut

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