AGC1 citrin [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: AGC1
Gene description: citrin
Primary source: SGD:S000006225
Locus tag: YPR021C
See related: AllianceGenome:SGD:S000006225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables acidic amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and cellular nitrogen compound biosynthetic process. Located in vacuole-mitochondrion membrane contact site. Used to study citrullinemia; common bile duct disease; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); citrullinemia (multiple); and developmental and epileptic encephalopathy (multiple). Orthologous to several human genes including SLC25A13 (solute carrier family 25 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p
Title: Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uniporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

NP_015346.1

Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant