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HTS1 histidine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856145, updated on 4-Jan-2025

Summary

Official Symbol
HTS1
Official Full Name
histidine--tRNA ligase
Primary source
SGD:S000006237
Locus tag
YPR033C
See related
AllianceGenome:SGD:S000006237; FungiDB:YPR033C; VEuPathDB:YPR033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TS4572; TSM4572
Summary
Enables aminoacyl-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in histidyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See HTS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (637379..639019, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nto1p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene Arp7p Neighboring gene glutamate--ammonia ligase

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding  
enables RNA binding  
enables aminoacyl-tRNA ligase activity PubMed 
enables aminoacyl-tRNA ligase activity  
enables catalytic activity, acting on a tRNA  
enables histidine-tRNA ligase activity  
enables histidine-tRNA ligase activity  
enables mRNA binding PubMed 
enables sequence-specific mRNA binding PubMed 
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation  
involved_in histidyl-tRNA aminoacylation PubMed 
involved_in histidyl-tRNA aminoacylation  
involved_in histidyl-tRNA aminoacylation PubMed 
involved_in mitochondrial translation  
involved_in mitochondrial translation PubMed 
involved_in tRNA aminoacylation for protein translation  
involved_in translation  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytosol  
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion  
located_in mitochondrion PubMed 

General protein information

Preferred Names
histidine--tRNA ligase
NP_015358.1
  • Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    637379..639019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184130.1NP_015358.1  TPA: histidine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W443, P07263, Q12095
    UniProtKB/TrEMBL
    B5VTJ1, C7GQA5, C8ZJ57, G2WPL1, N1NW10
    Conserved Domains (1) summary
    PLN02972
    Location:56503
    PLN02972; Histidyl-tRNA synthetase
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