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HTS1 histidine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856145, updated on 11-Apr-2024

Summary

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Gene symbol
HTS1
Gene description
histidine--tRNA ligase
Primary source
SGD:S000006237
Locus tag
YPR033C
See related
AllianceGenome:SGD:S000006237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TS4572; TSM4572
Summary
Enables aminoacyl-tRNA ligase activity. Involved in histidyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease, axonal type 2W. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to several human genes including HARS1 (histidyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (637379..639019, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nto1p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene Arp7p Neighboring gene glutamate--ammonia ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identity elements of Saccharomyces cerevisiae tRNA(His). Nameki N, et al. Nucleic Acids Res, 1995 Feb 11. PMID 7885835, Free PMC Article
  2. The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae. Natsoulis G, et al. Cell, 1986 Jul 18. PMID 3521891
  3. Starvation for His-tRNAHis in yeast causes translational arrest without a high level of misincorporation of glutamine at histidine codons. Hirst K, et al. Curr Genet, 1992 Mar. PMID 1563042
  4. HTS1 encodes both the cytoplasmic and mitochondrial histidyl-tRNA synthetase of Saccharomyces cerevisiae: mutations alter the specificity of compartmentation. Chiu MI, et al. Genetics, 1992 Dec. PMID 1459448, Free PMC Article
  5. Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. Lageix S, et al. PLoS Genet, 2015 Feb. PMID 25695491, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tRNA specifically antagonizes HisRS/CTD association in vitro. These findings support a model wherein HisRS-CTD interaction facilitates the autoinhibitory function of the CTD in nonstarvation conditions, with tRNA binding eliciting kinase activation
    Title: Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.
  2. The requirement for the highly conserved G-1 residue of tRNAHis can be circumvented by overexpression of tRNAHis and its synthetase.
    Title: The requirement for the highly conserved G-1 residue of Saccharomyces cerevisiae tRNAHis can be circumvented by overexpression of tRNAHis and its synthetase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables histidine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histidyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in histidyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
histidine--tRNA ligase
NP_015358.1
  • Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    637379..639019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184130.1 → NP_015358.1  TPA: histidine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W443, P07263, Q12095
    UniProtKB/TrEMBL
    A0A8H4BU25, B5VTJ1, C7GQA5, C8ZJ57, G2WPL1, N1NW10
    Conserved Domains (1) summary
    PLN02972
    Location:56 → 503
    PLN02972; Histidyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07263.2

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