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ARO7 chorismate mutase ARO7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856173, updated on 17-May-2024

Summary

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Gene symbol
ARO7
Gene description
chorismate mutase ARO7
Primary source
FungiDB:YPR060C
Locus tag
YPR060C
See related
SGD:S000006264; AllianceGenome:SGD:S000006264; VEuPathDB:YPR060C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HGS1; OSM2; TYR7
Summary
Enables chorismate mutase activity. Involved in L-phenylalanine biosynthetic process and tyrosine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARO7 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (674861..675631, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Brr1p Neighboring gene organic acid transporter Neighboring gene Jid1p Neighboring gene cytosine deaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel chorismate mutase from Erysiphe quercicola performs dual functions of synthesizing amino acids and inhibiting plant salicylic acid synthesis. He Q, et al. Microbiol Res, 2021 Jan. PMID 33010586
  2. The allosteric mechanism of yeast chorismate mutase: a dynamic analysis. Kong Y, et al. J Mol Biol, 2006 Feb 10. PMID 16337651
  3. Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase. Helmstaedt K, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 11997452, Free PMC Article
  4. The aroC gene of Aspergillus nidulans codes for a monofunctional, allosterically regulated chorismate mutase. Krappmann S, et al. J Biol Chem, 1999 Aug 6. PMID 10428795
  5. Yeast chorismate mutase in the R state: simulations of the active site. Ma J, et al. Proc Natl Acad Sci U S A, 1998 Dec 8. PMID 9843942, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chorismate mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chorismate mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chorismate mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-phenylalanine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aromatic amino acid family biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
chorismate mutase ARO7
NP_015385.1
  • Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    674861..675631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184157.1 → NP_015385.1  TPA: chorismate mutase ARO7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W465, P32178
    UniProtKB/TrEMBL
    A0A6A5Q2J8, A6ZWU8, B3LLB4, C7GY46, C8ZJ85, G2WPN3, N1NW21
    Conserved Domains (1) summary
    TIGR01802
    Location:10 → 255
    CM_pl-yst; monofunctional chorismate mutase, eukaryotic type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32178.1

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