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FCY1 cytosine deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856175, updated on 4-Jan-2025

Summary

Official Symbol
FCY1
Official Full Name
cytosine deaminase
Primary source
SGD:S000006266
Locus tag
YPR062W
See related
AllianceGenome:SGD:S000006266; FungiDB:YPR062W; VEuPathDB:YPR062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytosine deaminase activity. Involved in cytidine metabolic process; cytosine metabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See FCY1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (677165..677641)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene chorismate mutase ARO7 Neighboring gene Jid1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytosine deaminase activity  
enables cytosine deaminase activity PubMed 
enables cytosine deaminase activity  
enables deaminase activity  
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity  
enables hydrolase activity  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines  
enables metal ion binding  
enables zinc ion binding  
enables zinc ion binding PubMed 
Process Evidence Code Pubs
involved_in UMP salvage  
involved_in cytidine metabolic process  
involved_in cytidine metabolic process PubMed 
involved_in cytosine metabolic process  
involved_in cytosine metabolic process PubMed 
involved_in nucleobase-containing compound biosynthetic process  
involved_in pyrimidine-containing compound salvage  
involved_in pyrimidine-containing compound salvage PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
cytosine deaminase
NP_015387.1
  • Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    677165..677641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184159.1NP_015387.1  TPA: cytosine deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015387.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W467, Q12178
    UniProtKB/TrEMBL
    A6ZWV0, B3LLB6, C7GY48, C8ZJ87, G2WPN5, N1P257
    Conserved Domains (1) summary
    COG0590
    Location:6147
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
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