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THI22 putative phosphomethylpyrimidine kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856239, updated on 11-Apr-2024

Summary

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Gene symbol
THI22
Gene description
putative phosphomethylpyrimidine kinase
Primary source
SGD:S000006325
Locus tag
YPR121W
See related
AllianceGenome:SGD:S000006325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydroxymethylpyrimidine kinase activity and phosphomethylpyrimidine kinase activity. Involved in thiamine biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (778583..780301)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB5 Neighboring gene tRNA-Cys Neighboring gene Axl1p Neighboring gene high-affinity Cu transporter CTR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. Kawasaki Y, et al. Curr Genet, 2005 Mar. PMID 15614489
  2. Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Llorente B, et al. Mol Microbiol, 1999 Jun. PMID 10383756
  3. A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation. De Muyt A, et al. Genes Dev, 2018 Feb 1. PMID 29440262, Free PMC Article
  4. The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Bussey H, et al. Nature, 1997 May 29. PMID 9169875
  5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydroxymethylpyrimidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphomethylpyrimidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomethylpyrimidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative phosphomethylpyrimidine kinase
NP_015446.2
  • Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    778583..780301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184218.2 → NP_015446.2  TPA: putative phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015446.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4C0, Q06490
    UniProtKB/TrEMBL
    A0A8H4F8C3, A6ZX02, B3LK85, B5VTR1, C7GLI4
    Conserved Domains (2) summary
    COG0351
    Location:44 → 317
    ThiD; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]
    COG0819
    Location:352 → 572
    TenA; Thiaminase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06490.2

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