GDB1 bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GDB1
Gene description: bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase
Primary source: SGD:S000006388
Locus tag: YPR184W
See related: AllianceGenome:SGD:S000006388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Involved in glycogen catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (902044..906654)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that the N-terminal domain (1-644) alone has both alpha-1,4-transferase and the alpha-1,6-glucosidase activities.
Title: Association of bi-functional activity in the N-terminal domain of glycogen debranching enzyme.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-alpha-glucanotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-alpha-glucanotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-alpha-glucanotransferase activity	IEA Inferred from Electronic Annotation more info
enables 4-alpha-glucanotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables amylo-alpha-1,6-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amylo-alpha-1,6-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables amylo-alpha-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables amylo-alpha-1,6-glucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-maltose 4-alpha-glucanotransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase

NP_015510.1

EC 2.4.1.25

EC 3.2.1.33

Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

902044..906654

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184281.1 → NP_015510.1 TPA: bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015510.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4I4, O93808, Q06625

UniProtKB/TrEMBL

A0A8H4F8H3, A6ZX58, C7GP66, C8ZJL3

Conserved Domains (1) summary

TIGR01531
Location:26 → 1528

glyc_debranch; glycogen debranching enzymye