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DIA4 putative serine--tRNA ligase DIA4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856402, updated on 17-May-2024

Summary

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Gene symbol
DIA4
Gene description
putative serine--tRNA ligase DIA4
Primary source
FungiDB:YHR011W
Locus tag
YHR011W
See related
SGD:S000001053; AllianceGenome:SGD:S000001053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables serine-tRNA ligase activity. Involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (127780..129120)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Tda3p Neighboring gene ribosomal 60S subunit protein L27A Neighboring gene retromer subunit VPS29 Neighboring gene peptide alpha-N-acetyltransferase complex A subunit ARD1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maize seryl-tRNA synthetase: specificity of substrate recognition by the organellar enzyme. Rokov-Plavec J, et al. Arch Biochem Biophys, 2002 Jan 1. PMID 11747308
  2. Seryl transfer ribonucleic acid synthetase from bakers' yeast. 3. The seryladenylate-enzyme complex and its interaction with transfer ribonucleic acids. Bluestein HG, et al. J Biol Chem, 1968 Sep 25. PMID 4879089
  3. Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. Yokogawa T, et al. J Biol Chem, 2000 Jun 30. PMID 10764807
  4. Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Low JK, et al. Proteomics, 2016 Feb. PMID 26572822
  5. Functional discovery via a compendium of expression profiles. Hughes TR, et al. Cell, 2000 Jul 7. PMID 10929718

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial seryl-tRNA aminoacylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
putative serine--tRNA ligase DIA4
NP_011875.1
  • Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    127780..129120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179141.1 → NP_011875.1  TPA: putative serine--tRNA ligase DIA4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV6, P38705
    UniProtKB/TrEMBL
    A0A6V8RTR2, A6ZSR5, B3LSD2, B5VJT6, C7GMQ0, C8ZA78, G2WF79, N1P2Q8
    Conserved Domains (1) summary
    TIGR00414
    Location:1 → 440
    serS; seryl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38705.1

Gene LinkOut

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