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DED81 asparagine--tRNA ligase DED81 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856412, updated on 17-May-2024

Summary

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Gene symbol
DED81
Gene description
asparagine--tRNA ligase DED81
Primary source
FungiDB:YHR019C
Locus tag
YHR019C
See related
SGD:S000001061; AllianceGenome:SGD:S000001061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables asparagine-tRNA ligase activity. Involved in asparaginyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (141894..143558, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ysc83p Neighboring gene argininosuccinate lyase ARG4 Neighboring gene proline--tRNA ligase Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of YHR019 in Saccharomyces cerevisiae chromosome VIII as the gene for the cytosolic asparaginyl-tRNA synthetase. Landrieu I, et al. Yeast, 1998 Apr 30. PMID 9605503
  2. Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast. Thierry A, et al. G3 (Bethesda), 2016 May 3. PMID 26945028, Free PMC Article
  3. Comprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases. Garin S, et al. RNA Biol, 2021 Dec. PMID 34039240, Free PMC Article
  4. Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. Willis IM, et al. PLoS Genet, 2008 Jul 4. PMID 18604275, Free PMC Article
  5. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Richardson LA, et al. Cell Rep, 2012 Aug 30. PMID 22902402, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparagine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in asparaginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IC
Inferred by Curator
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
asparagine--tRNA ligase DED81
NP_011883.1
  • Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    141894..143558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179149.1 → NP_011883.1  TPA: asparagine--tRNA ligase DED81 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKW4, P38707
    UniProtKB/TrEMBL
    A0A8H4C1U7, A6ZSS3, B3LSD9, C7GXA7, C8ZA86, N1P541
    Conserved Domains (1) summary
    COG0017
    Location:116 → 554
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38707.1

Gene LinkOut

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