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QNS1 glutamine-dependent NAD(+) synthetase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856473, updated on 13-Apr-2024

Summary

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Gene symbol
QNS1
Gene description
glutamine-dependent NAD(+) synthetase
Primary source
SGD:S000001116
Locus tag
YHR074W
See related
AllianceGenome:SGD:S000001116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Involved in NAD biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (246193..248337)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene snoRNP complex protein NOP10 Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene phosphoprotein phosphatase methylesterase 1 Neighboring gene type 2C protein phosphatase PTC7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ancestral glutamine-dependent NAD(+) synthetase revealed by poor kinetic synergism. Resto M, et al. Biochim Biophys Acta, 2009 Nov. PMID 19647806
  2. Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals. Suda Y, et al. Yeast, 2003 Aug. PMID 12898714
  3. Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. Bieganowski P, et al. J Biol Chem, 2003 Aug 29. PMID 12771147
  4. Purification and properties of yeast nicotinamide adenine dinucleotide synthetase. Yi CK, et al. J Biol Chem, 1972 Aug 10. PMID 4340699
  5. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutamine-dependent NAD(+) synthetase
NP_011941.1
  • Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    246193..248337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179204.1 → NP_011941.1  TPA: glutamine-dependent NAD(+) synthetase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL24, P38795
    UniProtKB/TrEMBL
    A0A8H4BZQ3, A6ZSY1, B3LSJ2, B5VK03, C7GWT6, G2WFE7, N1P247
    Conserved Domains (1) summary
    PLN02339
    Location:4 → 704
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38795.1

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