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HXT4 hexose transporter HXT4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856492, updated on 11-Apr-2024

Summary

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Gene symbol
HXT4
Gene description
hexose transporter HXT4
Primary source
SGD:S000001134
Locus tag
YHR092C
See related
AllianceGenome:SGD:S000001134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LGT1; RAG1
Summary
Enables glucose transmembrane transporter activity and pentose transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (287081..288811, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase YNG2 Neighboring gene arginine--tRNA ligase MSR1 Neighboring gene Aht1p Neighboring gene hexose transporter HXT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of glucose on xylose utilization in Saccharomyces cerevisiae harboring the xylose reductase gene. Han JH, et al. Arch Microbiol, 2011 May. PMID 21279628
  2. Glucose sensing and signalling properties in Saccharomyces cerevisiae require the presence of at least two members of the glucose transporter family. Walsh MC, et al. J Bacteriol, 1996 May. PMID 8626327, Free PMC Article
  3. Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization. Hamacher T, et al. Microbiology (Reading), 2002 Sep. PMID 12213924
  4. Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast. Sedlak M, et al. Yeast, 2004 Jun. PMID 15197732
  5. Effects of the loss of mismatch repair genes on single-strand annealing between divergent sequences in Saccharomyces cerevisiae. Lim YS, et al. J Microbiol, 2021 Apr. PMID 33779953

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
    Title: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables pentose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hexose transporter HXT4
NP_011960.2
  • High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    287081..288811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179222.2 → NP_011960.2  TPA: hexose transporter HXT4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011960.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT02, D3DL44, P32467
    UniProtKB/TrEMBL
    A0A8H4C1Z5, G2WFG7
    Conserved Domains (1) summary
    pfam00083
    Location:74 → 534
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32467.1

Gene LinkOut

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