GRE3 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GRE3
Gene description: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
Primary source: SGD:S000001146
Locus tag: YHR104W
See related: AllianceGenome:SGD:S000001146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables D-xylose:NADP reductase activity and mRNA binding activity. Involved in cellular response to osmotic stress; cellular response to oxidative stress; and monosaccharide catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (323409..324392)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploiting the NADPH pool for xylitol production using recombinant Saccharomyces cerevisiae.
Title: Exploiting the NADPH pool for xylitol production using recombinant Saccharomyces cerevisiae.
findings show that cells overexpressing the aldose reductase GRE3, which converts galactose to galactitol, are more tolerant to lithium than wild-type cells when grown in galactose medium and they accumulate more galactitol and less galactose-1-phosphate
Title: Overexpression of the aldose reductase GRE3 suppresses lithium-induced galactose toxicity in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-xylose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables D-xylose reductase (NADPH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-xylose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in D-xylose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arabinose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arabinose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in galactose catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))

NP_011972.1

EC 1.1.1.21

Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

323409..324392

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179234.1 → NP_011972.1 TPA: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL54, P38715

UniProtKB/TrEMBL

A0A2S0UVX7, A6ZT12, B5VK39, C7GLZ0, C8Z9P7, G2WFH8, N1P141

Conserved Domains (1) summary

cl00470
Location:3 → 318

AKR_SF; Aldo-keto reductase (AKR) superfamily