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FUR1 uracil phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856529, updated on 17-May-2024

Summary

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Gene symbol
FUR1
Gene description
uracil phosphoribosyltransferase
Primary source
FungiDB:YHR128W
Locus tag
YHR128W
See related
SGD:S000001170; AllianceGenome:SGD:S000001170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables uracil phosphoribosyltransferase activity. Involved in pyrimidine-containing compound salvage. Predicted to be located in cytoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (362115..362765)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ans1p Neighboring gene uncharacterized protein Neighboring gene actin-related protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments. Pérez-Zúñiga FJ, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706399
  2. Molecular mechanisms of primary resistance to flucytosine in Candida albicans. Hope WW, et al. Antimicrob Agents Chemother, 2004 Nov. PMID 15504867, Free PMC Article
  3. Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae. Kern L, et al. Curr Genet, 1991 May. PMID 1913872
  4. Baker's yeast UMP:pyrophosphate phosphoribosyltransferase. Purification, enzymatic and kinetic properties. Natalini P, et al. J Biol Chem, 1979 Mar 10. PMID 216696
  5. Codon-optimized glucoamylase sGAI of Aspergillus awamori improves starch utilization in an industrial yeast. Favaro L, et al. Appl Microbiol Biotechnol, 2012 Aug. PMID 22450569

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uracil phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine-containing compound salvage IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
uracil phosphoribosyltransferase
NP_011996.2
  • Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    362115..362765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179258.1 → NP_011996.2  TPA: uracil phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011996.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL77, P18562
    UniProtKB/TrEMBL
    A0A6A5PZT4, A6ZT35, B3LSP2, B5VK61, C7GR72, C8Z9S1, G2WFK1, N1P9F6
    Conserved Domains (1) summary
    pfam14681
    Location:14 → 214
    UPRTase; Uracil phosphoribosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18562.2

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