U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DCD1 deoxycytidine monophosphate deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856548, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
DCD1
Gene description
deoxycytidine monophosphate deaminase
Primary source
SGD:S000001187
Locus tag
YHR144C
See related
AllianceGenome:SGD:S000001187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dCMP deaminase activity. Involved in dTMP biosynthetic process and dUMP biosynthetic process. Located in cytoplasm. Orthologous to several human genes including DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (387788..388726, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dse2p Neighboring gene DNA-directed RNA polymerase core subunit RPC10 Neighboring gene tRNA-Pro Neighboring gene Crp1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeast. Liskay RM, et al. Curr Biol, 2007 Sep 4. PMID 17803923, Free PMC Article
  2. Elevated intracellular dCTP levels reduce the induction of GC-->AT transitions in yeast by ethyl methanesulfonate or N-methyl-N'-nitro-N- nitrosoguanidine but increase alkylation-induced GC-->CG transversions. Kohalmi SE, et al. Mutagenesis, 1993 Sep. PMID 8231828
  3. Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme. McIntosh EM, et al. J Bacteriol, 1984 May. PMID 6373725, Free PMC Article
  4. Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae. McIntosh EM, et al. Mol Cell Biol, 1986 May. PMID 3023902, Free PMC Article
  5. Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate. Kohalmi SE, et al. J Mol Biol, 1991 Aug 20. PMID 1880805

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dUMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
deoxycytidine monophosphate deaminase
NP_012014.1
  • Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    387788..388726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179275.1 → NP_012014.1  TPA: deoxycytidine monophosphate deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL94, P06773
    UniProtKB/TrEMBL
    A0A6A5PW45, A6ZT53, B3LSQ9, C7GXW5, G2WFL8, N1P2C6
    Conserved Domains (1) summary
    COG2131
    Location:159 → 312
    ComEB; Deoxycytidylate deaminase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06773.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools