IMD2 IMP dehydrogenase IMD2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: IMD2
Gene description: IMP dehydrogenase IMD2
Primary source: SGD:S000001259
Locus tag: YHR216W
See related: AllianceGenome:SGD:S000001259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PUR5
Summary: Enables chromatin binding activity. Predicted to be involved in GTP biosynthetic process. Located in chromatin and cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (554396..555967)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IMD2, located near the boundary of heterochromatin regions, is regulated by multiple HAT-related factors.
Title: IMD2, located near the boundary of heterochromatin regions, is regulated by multiple HAT-related factors.
Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1
Title: Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.
analysis of an intergenic terminator and start site switch that regulate IMD2 transcription in S. cerevisiae
Title: Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast.
These findings support a model in which intergenic short transcripts emanating from upstream of the IMD2 promoter are terminated by a polyadenylation/terminator-like signal embedded within the IMD2 transcription start site.
Title: Metabolic regulation of IMD2 transcription and an unusual DNA element that generates short transcripts.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables IMP dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables IMP dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: IMP dehydrogenase IMD2

NP_012088.3

EC 1.1.1.205

Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

554396..555967

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179347.3 → NP_012088.3 TPA: IMP dehydrogenase IMD2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012088.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLH1, P38697

UniProtKB/TrEMBL

A0A8H4F9Z9, C8Z7M4, G2WDJ8

Conserved Domains (1) summary

PTZ00314
Location:21 → 518

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional