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GLC3 1,4-alpha-glucan branching enzyme [ Saccharomyces cerevisiae S288C ]

Gene ID: 856705, updated on 11-Apr-2024

Summary

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Gene symbol
GLC3
Gene description
1,4-alpha-glucan branching enzyme
Primary source
SGD:S000000737
Locus tag
YEL011W
See related
AllianceGenome:SGD:S000000737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GHA1
Summary
Enables 1,4-alpha-glucan branching enzyme activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Used to study glycogen storage disease IV. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (133120..135234)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene E2 ubiquitin-conjugating protein UBC8 Neighboring gene tRNA-Lys Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GLC3 and GHA1 of Saccharomyces cerevisiae are allelic and encode the glycogen branching enzyme. Rowen DW, et al. Mol Cell Biol, 1992 Jan. PMID 1729600, Free PMC Article
  2. Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae. Induction of glycogen branching enzyme. Thon VJ, et al. J Biol Chem, 1992 Jul 25. PMID 1634552
  3. Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth. Shi L, et al. Mol Biol Cell, 2010 Jun 15. PMID 20427572, Free PMC Article
  4. Isolation of human glycogen branching enzyme cDNAs by screening complementation in yeast. Thon VJ, et al. J Biol Chem, 1993 Apr 5. PMID 8463281
  5. Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability. Persson LB, et al. Cell, 2020 Dec 10. PMID 33157040, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1,4-alpha-glucan branching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,4-alpha-glucan branching enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables 1,4-alpha-glucan branching enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1,4-alpha-glucan branching enzyme
NP_010905.1
  • Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    133120..135234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178826.1 → NP_010905.1  TPA: 1,4-alpha-glucan branching enzyme [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010905.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLN8, P32775
    UniProtKB/TrEMBL
    A0A6A5Q0U4, A6ZQT8, B3LS05, C8Z6Y9, G2WCM1, N1P5D9
    Conserved Domains (1) summary
    PLN02447
    Location:9 → 702
    PLN02447; 1,4-alpha-glucan-branching enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32775.2

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