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SAH1 adenosylhomocysteinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856766, updated on 4-Jan-2025

Summary

Official Symbol
SAH1
Official Full Name
adenosylhomocysteinase
Primary source
SGD:S000000845
Locus tag
YER043C
See related
AllianceGenome:SGD:S000000845; FungiDB:YER043C; VEuPathDB:YER043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process; phosphatidylcholine biosynthetic process; and triglyceride metabolic process. Located in cytoplasm. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; hyperhomocysteinemia; and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See SAH1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (235770..237119, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene Erg28p Neighboring gene Mei4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenosylhomocysteinase activity  
enables adenosylhomocysteinase activity  
enables adenosylhomocysteinase activity PubMed 
enables hydrolase activity  
Component Evidence Code Pubs
located_in cytoplasm PubMed 
is_active_in cytosol  

General protein information

Preferred Names
adenosylhomocysteinase
NP_010961.3
  • S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    235770..237119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178934.3NP_010961.3  TPA: adenosylhomocysteinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010961.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLU3, P39954
    UniProtKB/TrEMBL
    A6ZQZ2, B3LS56, B5VHH7, C7GSJ0, C8Z746, G2WCS6, N1P540
    Conserved Domains (1) summary
    smart00996
    Location:9448
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
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