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HIS1 ATP phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856782, updated on 5-May-2024

Summary

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Gene symbol
HIS1
Gene description
ATP phosphoribosyltransferase
Primary source
SGD:S000000857
Locus tag
YER055C
See related
AllianceGenome:SGD:S000000857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP phosphoribosyltransferase activity. Involved in histidine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (264892..265785, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gip2p Neighboring gene purine-cytosine permease Neighboring gene ribosomal 60S subunit protein L34A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Further evidence of a disparity between conversion and restoration in the his1 locus of Saccharomyces cerevisiae. Hastings PJ, et al. Curr Genet, 1984 Jan. PMID 24177525
  2. Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. II. Complementation Mapping of Mutants and a Subunit Model of the Enzyme. Korch CT. Genetics, 1973 Jun. PMID 17248619, Free PMC Article
  3. Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. Hinnebusch AG, et al. J Biol Chem, 1983 Apr 25. PMID 6300123
  4. Novel interallelic complementation at the his1 locus of yeast. Lax C, et al. Genetics, 1978 Nov. PMID 365680, Free PMC Article
  5. Mutagenic and antioxidant activities of Croton lechleri sap in biological systems. Lopes MI, et al. J Ethnopharmacol, 2004 Dec. PMID 15507372

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP phosphoribosyltransferase
NP_010975.3
  • ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    264892..265785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178946.3 → NP_010975.3  TPA: ATP phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010975.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLV8, P00498
    UniProtKB/TrEMBL
    A0A8H8ULS1, A6ZR07, C7GX46, C8Z760, G2WCU1, N1P551
    Conserved Domains (1) summary
    COG0040
    Location:9 → 297
    HisG; ATP phosphoribosyltransferase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00498.1

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