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FCY2 purine-cytosine permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 856783, updated on 13-Apr-2024

Summary

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Gene symbol
FCY2
Gene description
purine-cytosine permease
Primary source
SGD:S000000858
Locus tag
YER056C
See related
AllianceGenome:SGD:S000000858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BRA7
Summary
Enables cytidine transmembrane transporter activity and nucleobase transmembrane transporter activity. Involved in cytidine transport; cytosine transport; and purine-containing compound transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (266512..268113, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Gip2p Neighboring gene ATP phosphoribosyltransferase Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene putative isoleucine biosynthesis protein HMF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for a dynamic role for proline376 in the purine-cytosine permease of Saccharomyces cerevisiae. Ferreira T, et al. Eur J Biochem, 1999 Jul. PMID 10429187
  2. Screening of an intragenic second-site suppressor of purine-cytosine permease from Saccharomyces cerevisiae. Possible role of Ser272 in the base translocation process. Ferreira T, et al. Eur J Biochem, 1999 Feb. PMID 10091580
  3. Characterization of the Saccharomyces cerevisiae cytosine transporter using energizable plasma membrane vesicles. Pinson B, et al. J Biol Chem, 1997 Nov 14. PMID 9360962
  4. Functional analysis of mutated purine-cytosine permease from Saccharomyces cerevisiae. A possible role of the hydrophilic segment 371-377 in the active carrier conformation. Ferreira T, et al. J Biol Chem, 1997 Apr 11. PMID 9092500
  5. Cytosine accumulation as a measure of the proton electrochemical gradient acting on the overexpressed cytosine permease of Saccharomyces cerevisiae. Eddy AA, et al. Microbiology (Reading), 1996 Mar. PMID 8868419

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleobase transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytidine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytidine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytosine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytosine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine-containing compound transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
purine-cytosine permease
NP_010976.1
  • Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    266512..268113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178947.1 → NP_010976.1  TPA: purine-cytosine permease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLV9, P17064
    UniProtKB/TrEMBL
    A0A8H8ULS2, C8Z761
    Conserved Domains (1) summary
    COG1457
    Location:65 → 533
    CodB; Purine-cytosine permease or related protein [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17064.2

Gene LinkOut

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