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FCY22 purine-cytosine permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 856789, updated on 23-Nov-2023

Summary

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Gene symbol
FCY22
Gene description
purine-cytosine permease
Primary source
SGD:S000002958
Locus tag
YER060W-A
See related
AllianceGenome:SGD:S000002958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nucleobase transmembrane transporter activity. Involved in cytosine transport. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (276572..278164)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Pcl6p Neighboring gene purine-cytosine permease Neighboring gene fatty acid synthase CEM1 Neighboring gene glycerol-1-phosphatase HOR2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New plasmid system to select for Saccharomyces cerevisiae purine-cytosine permease affinity mutants. Wagner R, et al. J Bacteriol, 2001 Jul. PMID 11418581, Free PMC Article
  2. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski JP, et al. Yeast, 2006 Jul 15. PMID 16845689
  3. Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae. Linderholm AL, et al. Appl Environ Microbiol, 2008 Mar. PMID 18192430, Free PMC Article
  4. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article
  5. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleobase transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytosine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytosine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine-containing compound transmembrane transport ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
purine-cytosine permease
NP_010982.1
  • Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    276572..278164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180858.1 → NP_010982.1  TPA: purine-cytosine permease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010982.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLW5, Q12119
    UniProtKB/TrEMBL
    A0A8H8ULS7, N1P3E2
    Conserved Domains (1) summary
    COG1457
    Location:62 → 530
    CodB; Purine-cytosine permease or related protein [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12119.1

Gene LinkOut

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