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ARG56 bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856800, updated on 17-May-2024

Summary

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Gene symbol
ARG56
Gene description
bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
Primary source
FungiDB:YER069W
Locus tag
YER069W
See related
SGD:S000000871; AllianceGenome:SGD:S000000871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables N-acetyl-gamma-glutamyl-phosphate reductase activity and acetylglutamate kinase activity. Involved in regulation of transcription, DNA-templated. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARG56 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (295410..298001)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Rgi1p Neighboring gene CCR4-NOT core ubiquitin-protein ligase subunit MOT2 Neighboring gene ribonucleotide-diphosphate reductase subunit RNR1 Neighboring gene Tda2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-level production of ornithine by expression of the feedback inhibition-insensitive N-acetyl glutamate kinase in the sake yeast Saccharomyces cerevisiae. Ohashi M, et al. Metab Eng, 2020 Nov. PMID 32805427
  2. Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase. de Cima S, et al. PLoS One, 2012. PMID 22529931, Free PMC Article
  3. Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Boonchird C, et al. Mol Gen Genet, 1991 Apr. PMID 1851947
  4. More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites. Friedl J, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997570, Free PMC Article
  5. N5-phosphonoacetyl-L-ornithine (PALO): a convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae. Johnson B, et al. Bioorg Med Chem Lett, 2011 Apr 15. PMID 21421312

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables acetylglutamate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglutamate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylglutamate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alpha-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in ornithine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
NP_010992.1
  • Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    295410..298001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178960.1 → NP_010992.1  TPA: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLX4, Q01217
    UniProtKB/TrEMBL
    A0A8H8ULT6, A6ZR23, B3LRI6, B5VHJ9, C7GRQ1
    Conserved Domains (3) summary
    cd04252
    Location:100 → 348
    AAK_NAGK-fArgBP; N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal reductase domain ...
    TIGR01850
    Location:542 → 856
    argC; N-acetyl-gamma-glutamyl-phosphate reductase, common form
    pfam04768
    Location:333 → 499
    NAT; N-acetyltransferase, of N-acetylglutamate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01217.1

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