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ILV1 threonine ammonia-lyase ILV1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856819, updated on 11-Apr-2024

Summary

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Gene symbol
ILV1
Gene description
threonine ammonia-lyase ILV1
Primary source
SGD:S000000888
Locus tag
YER086W
See related
AllianceGenome:SGD:S000000888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ISO1
Summary
Enables L-threonine ammonia-lyase activity. Involved in isoleucine biosynthetic process and threonine catabolic process. Located in mitochondrion. Orthologous to human SDS (serine dehydratase) and SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (328477..330207)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Arf family guanine nucleotide exchange factor SBH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neither Reb1p nor poly(dA*T) elements are responsible for the highly specific chromatin organization at the ILV1 promoter. Moreira JM, et al. J Biol Chem, 2002 Feb 1. PMID 11706001
  2. Datin, a yeast poly(dA:dT)-binding protein, behaves as an activator of the wild-type ILV1 promoter and interacts synergistically with Reb1p. Moreira JM, et al. Mol Gen Genet, 1998 Apr. PMID 9613577
  3. Intragenic complementation, hybrid enzyme formation and dominance in diploid cells of Saccharomyces cerevisiae. Zimmermann FK, et al. Mol Gen Genet, 1969. PMID 5803903
  4. The regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. I. Threonine deaminase. Robichon-Szulmajster H, et al. Eur J Biochem, 1968 Feb. PMID 5642456
  5. Threonine deaminases from Saccharomyces cerevisiae mutationally altered in regulatory properties. Betz JL, et al. Biochemistry, 1971 May 11. PMID 5563764

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substitution of histone H3 arginine 72 to alanine leads to the deregulation of isoleucine biosynthesis in the budding yeast Saccharomyces cerevisiae.
    Title: Substitution of histone H3 arginine 72 to alanine leads to the deregulation of isoleucine biosynthesis in the budding yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonine catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
threonine ammonia-lyase ILV1
NP_011009.1
  • Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    328477..330207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178977.1 → NP_011009.1  TPA: threonine ammonia-lyase ILV1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011009.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLZ2, P00927
    UniProtKB/TrEMBL
    A0A6A5PYH0, A6ZR41, B3LRK3, C7GRR8, C8Z799, G2WCX6, N1P3G3
    Conserved Domains (1) summary
    PRK09224
    Location:61 → 575
    PRK09224; threonine ammonia-lyase IlvA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00927.2

Gene LinkOut

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