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AIM10 putative proline--tRNA ligase AIM10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856820, updated on 13-Apr-2024

Summary

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Gene symbol
AIM10
Gene description
putative proline--tRNA ligase AIM10
Primary source
SGD:S000000889
Locus tag
YER087W
See related
AllianceGenome:SGD:S000000889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (330576..332306)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene threonine ammonia-lyase ILV1 Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene Dot6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a putative prolyl-tRNA synthetase (CaPRS) gene from Candida albicans. Sentandreu M, et al. Yeast, 1997 Nov. PMID 9392082
  2. Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain. SternJohn J, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17283340, Free PMC Article
  3. A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia. Bunjun S, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11078517, Free PMC Article
  4. Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases. Ahel I, et al. J Biol Chem, 2002 Sep 20. PMID 12130657
  5. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables proline-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prolyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative proline--tRNA ligase AIM10
NP_011010.1
  • Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    330576..332306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178978.1 → NP_011010.1  TPA: putative proline--tRNA ligase AIM10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011010.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLZ3, P39965
    UniProtKB/TrEMBL
    A0A6A5Q145, A6ZR42, B3LRK4, C8Z7A0, G2WCX7, N1PA48
    Conserved Domains (1) summary
    COG0442
    Location:9 → 530
    ProS; Prolyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39965.1

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