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AVT6 aspartate/glutamate transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856855, updated on 25-Apr-2024

Summary

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Gene symbol
AVT6
Gene description
aspartate/glutamate transporter
Primary source
SGD:S000000921
Locus tag
YER119C
See related
AllianceGenome:SGD:S000000921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane. Orthologous to several human genes including SLC38A7 (solute carrier family 38 member 7) and SLC38A8 (solute carrier family 38 member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (399496..400842, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L23B Neighboring gene osmosensor SHO1 Neighboring gene phosphatidylinositol-binding protein SCS2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for Avt6 as a vacuolar exporter of acidic amino acids in Saccharomyces cerevisiae cells. Chahomchuen T, et al. J Gen Appl Microbiol, 2009 Dec. PMID 20118605
  2. The vacuolar amino acid transport system is a novel, direct target of GATA transcription factors. Sato A, et al. Biosci Biotechnol Biochem, 2021 Feb 24. PMID 33624780
  3. Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae. Nishida I, et al. J Gen Appl Microbiol, 2016 Jul 14. PMID 27246536
  4. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. Russnak R, et al. J Biol Chem, 2001 Jun 29. PMID 11274162
  5. Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae. Lawrence MBD, et al. Genetics, 2017 Sep. PMID 28739661, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-aspartate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-tyrosine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-serine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane export from vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartate/glutamate transporter
NP_011044.1
  • Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    399496..400842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179009.1 → NP_011044.1  TPA: aspartate/glutamate transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM25, P40074
    UniProtKB/TrEMBL
    A0A8H8ULY3, A6ZR74, G2WD05, N1P3J6
    Conserved Domains (1) summary
    pfam01490
    Location:1 → 439
    Aa_trans; Transmembrane amino acid transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40074.1

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