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FAU1 5-formyltetrahydrofolate cyclo-ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856932, updated on 11-Apr-2024

Summary

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Gene symbol
FAU1
Gene description
5-formyltetrahydrofolate cyclo-ligase
Primary source
SGD:S000000985
Locus tag
YER183C
See related
AllianceGenome:SGD:S000000985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 5-formyltetrahydrofolate cyclo-ligase activity. Involved in folic acid-containing compound biosynthetic process. Located in mitochondrion. Orthologous to several human genes including ST20-MTHFS (ST20-MTHFS readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (553334..553969, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fmp10p Neighboring gene Tog1p Neighboring gene Pug1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of methenyltetrahydrofolate synthetase from Saccharomyces cerevisiae. Holmes WB, et al. J Biol Chem, 2002 Jun 7. PMID 11923304
  2. Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule. Rébora K, et al. Genetics, 2005 May. PMID 15744050, Free PMC Article
  3. Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae. Saint-Marc C, et al. Curr Genet, 2015 Nov. PMID 25893566
  4. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. Wang Y, et al. J Cell Biol, 2020 May 4. PMID 32303746, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-formyltetrahydrofolate cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-formyltetrahydrofolate cyclo-ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in folic acid-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in folic acid-containing compound biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-formyltetrahydrofolate cyclo-ligase
NP_011110.1
  • 5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    553334..553969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179073.1 → NP_011110.1  TPA: 5-formyltetrahydrofolate cyclo-ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM92, P40099
    UniProtKB/TrEMBL
    A0A8H8UM47, A6ZRE0, B3LRU3, B5VHW4, C7GUZ3
    Conserved Domains (1) summary
    pfam01812
    Location:4 → 203
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40099.1

Gene LinkOut

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